Scheduled for October 5, 2025, at Lucas Oil Stadium in Indianapolis, the Las Vegas Raiders will take on the Indianapolis Colts in a highly anticipated NFL game, starting at 1:00 pm.

Last season, the Raiders finished 4th in their division and 10th in the conference with a 1-3-0 record, scoring 77 points and surrendering 99, resulting in a -22 point difference. On the other hand, the Colts led their division and ranked 4th in the conference with a 3-1-0 record, scoring 123 points while conceding 83, which gives them a positive point difference of 40.

Details from last week’s games for both teams are not available, but pivotal to this matchup will be the quarterbacks. Gardner Minshew II will be at the helm for the Raiders, while Anthony Richardson will guide the Colts.

For more updates on this and other matches, keep an eye on betIndianasports.com.

In regards to betting, the Colts are favored with a point spread of -8.00, suggesting strong confidence in their performance at home. Conversely, the Raiders have been allocated a point spread of +9.10, reflecting their underdog status. Additionally, with an over/under set at 54.20, it indicates expectations of a high-scoring game. For those considering direct bets, the odds stand at -370 for the Colts and +296 for the Raiders. These figures imply the Colts have a significant likelihood of securing a win, whereas the Raiders are the risky, yet potentially rewarding choice for bettors seeking higher returns.