On November 2, 2025, an enthralling NFL showdown is set to take place as the Indianapolis Colts take on the Pittsburgh Steelers at Acrisure Stadium in Pittsburgh, starting at 1:00 PM.

During the 2024 NFL season, the Colts showcased strong form by ranking first in their division and fourth in their conference with a 3-1-0 record, marking a 75% win rate. They outscored opponents by 40 points, with 123 points for and 83 against. The Steelers, matching the Colts with a 3-1-0 record and a 75% win rate, faced closer contests, scoring 96 points while conceding 98, resulting in a minor negative point differential of -2.

In recent matchups, the Colts earned a tough win against Miami with a final score of 16-10, where Anthony Richardson impressed with 129 passing yards, despite not throwing any touchdowns and finishing with a 59.2 passer rating. The Steelers, meanwhile, dominated the New York Jets 37-15, propelled by Russell Wilson’s strong performance of 264 passing yards and two touchdowns, earning a passer rating of 108.98.

Quarterback play will be crucial in this upcoming game, as both Richardson and Wilson look to leverage their recent performances. Richardson aims to enhance his scoring output, while Wilson seeks to maintain his high efficiency.

As for sports betting enthusiasts, the odds have the Steelers favored by 3.50 points at home. The over/under for the game is pegged at 44.70, suggesting expectations of a moderately high-scoring affair. For those looking to wager, the moneyline has the Steelers at -181 and the Colts at +151, indicating a tilt towards Pittsburgh as the more favored team.