The upcoming NFL face-off between the Indianapolis Colts and the Los Angeles Chargers is set for October 19, 2025, at the SoFi Stadium in Inglewood, starting at 4:05 PM. Last season saw the Colts leading their division and placing fourth in the conference with a strong 3-1 record and a 0.75 win ratio. They’ve managed to score 123 points while conceding 83, giving them a positive net point differential of 40. Similarly, the Chargers also stand first in their division and third in their conference with an identical record and win percentage, accumulating 88 points for and 71 against, resulting in a 17-point differential. In their recent encounters, the Colts edged out the Tennessee Titans with a 20-17 victory, securing 20 first downs, and aggregating 80 rushing and 189 passing yards. The Chargers, on the other hand, defeated the Denver Broncos 23-16, notching 22 first downs, 128 rushing yards, and 222 passing yards. Colts’ quarterback Joe Flacco threw for 189 yards and two touchdowns with a passer rating of 77.63, while Chargers’ Justin Herbert passed for 237 yards, one touchdown, registering a passer rating of 92.4. This sets the stage for what promises to be a captivating quarterback duel in the upcoming match. Regarding the betting odds, the Chargers are favored at home with a point spread of -6.40, while the Colts are underdogs with a spread of +6.90. The game’s total points (over/under) has been set at 48.80. The moneyline betting has the Chargers at -284 and the Colts at +230. Given the statistical parity and recent performances, this game promises not only thrilling football action but also intriguing opportunities for sports bettors.